Xu Lab @ Tufts BME


  1. Wang, M.; Zuris, J. A.; Meng, F.T.; Rees, H.; Deng, P.; Gao, X.; Pouli, D.; Wu, Q.; Georgakoudi, I.; Liu, D. R.*; Xu, Q.* “Efficient Genome Editing Protein Delivery using Bioreducible Lipid-like Materials”, 2016, Proceedings of the National Academy of Sciences, 113, 2868-2873.
  2. Domigan, L. J.; Andersson, M.; Alberti, K. A.; Chesler, M.; Xu, Q. Johansson, J.; Rising, A.; Kaplan, D. L.”Carbonic anhydrase generates a pH gradient in Bombyx mori silk glands”, Insect Biochem Mol Biol. 2015, 65,100-106.
  3. Jabbari, E. *; Leijten, J.; Xu, Q. *; Khademhosseini, A.* “The matrix reloaded: the evolution of regenerative hydrogels”, Materials Today, 2015, Nov.
  4. Alberti, K. A.; Xu, Q.* “Biocompatibility and degradation of tendon-derived scaffolds”, Regenerative Biomaterials, 2015, 112015, 1–11.
  5. Wang, M.; Altinoglu, S.; Takeda, Y. S. Xu, Q.* “Integrating Protein Engineering and Bioorthogonal Click Conjugation for Extracellular Vesicle Modulation and Intracellular Delivery”, 2015, PLoS One, 10(11): e0141860.
  6. Takeda, Y. S.; Xu, Q.* “Neuronal Differentiation of Human Mesenchymal Stem Cells Using Exosomes Derived from Neural Progenitor Cells”, PLoS One, 2015, 10, e0135111.
  7. Takeda, Y. S.; Xu, Q.* “Synthetic and Nature-derived Lipid Nanoparticles for Neural Regeneration”, Nerve Regeneration Research, 2015, 10(5):689-90.
  8. Altınoǧlu, S.; Wang, M.; Xu, Q.* “Combinatorial Library Strategies for Synthesis of Cationic Lipid-like Nanoparticles and Their Potential Medical Applications”, Nanomedicine, 2015, 10(4): 643-57.
  9. Alberti, A.; Sun, J. Y.; Illeperuma, W. R.; Suo, Z.; Xu, Q.* “Laminar Tendon Composites with Enhanced Mechanical Properties”, Journal of Material Science, 2015, 50: 2616-25.
  10. Solhjou, Z.; Athar, H.; Xu, Q.; Abdi, R. “Emerging Therapies Targeting Intra-organ Inflammation in Transplantation”, American Journal of Transplantation, 2015, 15(2):305-11.
  11. Wang, M.; Sun, S.; Neufeld, C.; Perez-Ramirez, B.; Xu, Q.* “Reactive Oxygen Species (ROS)-Responsive Protein Modification and its Intracellular Delivery”, Angewandte Chemie International Edition, 2014, 53, 13444-13448.
  12. Wang, M.; Alberti, K. A.; Sun, S.; Xu, Q.* “Combinatorially designed lipid-like nanoparticles for intracellular delivery of cytotoxic protein for cancer therapy”, Angewandte Chemie International Edition, 2014, 53(11):2893-8.
  13. Alberti, K. A.; Hopkins, A.; Tang-Schomer, M.; Kaplan, D. L.; Xu, Q.* “The Behavior of Neuronal Cells on Tendon-Derived Collagen Sheets as Potential Substrates for Nerve Regeneration”, 2014, 35, 3551-3557.
  14. Wang, M.; Alberti, K. A.; Varone, A.; Pouli D.; Georgakoudi, I.; Xu, Q.* “Enhanced Intracellular siRNA Delivery Using Bioreducible Lipid-like Nanoparticles”, Advanced Healthcare Materials, 2014, 3, 1398-1403.
  15. Kuang, Y.; Shi, J.; Li, J.; Yuan, D.; Alberti, K.; Xu, Q.; Xu, B. “Pericellular Hydrogel/Nanonets Inhibit Cancer Cells”, Angewandte Chemie International Edition, 2014, 53, 8104-8107.
  16. Takeda, Y.; Xu, Q.* “Fabrication of 2D and 3D constructs from reconstituted decellularized tissue extracellular matrices”, Journal of Biomedical Nanotechnology, 2014, 10, 3631-3637.
  17. Wang, Q.; Xia, X.; Huang, W.; Lin, Y.; Xu, Q.; Kaplan, D. L. “High Throughput Screening of Dynamic Silk-Elastin-Like Protein Biomaterials”, Advanced Functional Materials, 2014, 24, 4303-4310.
  18. Xia, X. X.; Wang, M.; Lin, Y.; Xu, Q.; Kaplan, D. L. “Hydrophobic drug-triggered self-assembly of nanoparticles form silk-elastin-like protein polymers for drug delivery.” Biomacromolecules, 2014, 15, 908-914.
  19. Lin, Y.; Xia, X.; Wang, M.; Wang, Q.; An, B.; Hu, T.; Xu, Q.; Omenetto, F.; Kaplan, D. “Genetically Programmable Thermoresponsive Plasmonic Gold/Silk-Elastin Protein Core/Shell Nanoparticles”, Langmuir, 2014, 30, 4406-4414.
  20. Ameri, S. K.; Singh, P. K.; Dokmeci, M. R.; Khademhosseini, A.; Xu, Q.; Sonkusale, S. R. “All Electronic Approach for High-throughput Cell Trapping and Lysis with Electrical Impedance Monitoring,” Biosensors and Bioelectronics, 2014, 54, 462-467.
  21. Alberti, K. A.; Xu, Q.* “Slicing, Stacking and Rolling: Fabrication of Nanostructured Collagen Constructs from Tendon Sections”, Advanced Healthcare Materials, 2013, 2, 817–821.
  22. Sun S.; Wang, M.; Alberti, K. A.; Choy, A.; Xu, Q.* “DOPE Facilitates Quaternized Lipidoids (QLDs) for in vitro DNA Delivery”, Nanomedicine: NBM, 2013, 9, 849-854.
  23. Wang, M.; Sun S.; Alberti, K. A.; Xu, Q.* “A Combinatorial Library of Unsaturated Lipidoids for Efficient Intracellular Gene Delivery”, ACS Synthetic Biology, 2012, 1, 403–407.
  24. Sun, S.; Wang, M.; Knupp, S. A.; Soto-Feliciano, Y.; Hu, X.; Kaplan, D. L.; Anderson, D. G.; Langer, R.; Xu, Q.* “Combinatorial library of lipidoids for In vitro DNA delivery, Bioconjugate Chemistry, 2012, 23, 135–140.
  25. Dai, X.; Knupp, S.; Xu, Q.*, “Patterning Nanoparticles in 3D Matrix using Electric-Field Assisted Gel Transferring (EFAGT)”, Langmuir, 2012, 28, 2960-2964.
  26. Sant, S.; Tao, S.; Fisher, O.; Xu, Q.; Peppas, N. A.; Khademhosseini, A. “Microfabrication technologies for oral drug delivery”, Advanced Drug Delivery Reviews, 2012, 64, 496–507.
  27. Dai, X.; Schalek, R.; Xu, Q.* “Staining-and-Etching: a simple method to fabricate inorganic nanostructures from tissue slices”, Advanced Materials, 2012, 24, 370-374.
  28. Xia, X.; Xu, Q.; Hu, X.; Qin, G.; Kaplan, D. L. “Tunable Self-Assembly of Genetically Engineered Silk-Elastin Protein Polymers”, Biomacromolecules, 2011, 12 , 3844–3850.
  29. Dai, X.; Xu, Q.* “Nanostructured substrate fabricated by sectioning tendon using a microtome for tissue engineering”, Nanotechnology, 2011, 22, 494008.
  30. Huo, B.; Lu, X.L.; Costa K.D.; Xu, Q.; Guo, X. E. “An ATP-dependent mechanism mediates intercellular calcium signaling in bone cell network under single cell nanoindentation.” Cell Calcium, 2010, 47, 234-241.
  31. Cheng, H.; Kastrup, C.J.; Ramanathan, R.; Siegwart, D.J.; Ma, M.L.; Bogatyrev, S.R.; Xu, Q.; Whitehead, K. A.; Langer, R.; Anderson, D.G. “Nanoparticulate Cellular Patches for Cell-Mediated Tumoritropic Delivery.”, ACS Nano, 2010, 4, 625-631.
  32. Dang, T. T.; Xu, Q.; Bratlie, K. M.; Chen, I.; Langer, R.; Anderson, D. G. “Fabrication of Cell-laden Hydrogel Microcapsules Using Thermo-molded Polypropylene Mesh.” Biomaterials, 2009, 30, 6896-6902.
  33. Cho, S. W.; Goldberg, M.; Son, S. M.; Xu, Q.; Yang, F.; Mei, Y.; Bogatyrev, S.; Langer, R.; Anderson, D. G. “Lipid-like Nanoparticles for Small Interfering RNA Delivery to Endothelial Cells.” Advanced Functional Materials, 2009, 19, 112-3118.
  34. Xu, Q.; Hahsimoto, M.; Dang, T. T.; Hoare, T.; Kohane, D. S.; Whitesides, G. M.; Langer, R.; Anderson, D. G. “Preparation of Monodisperse Biodegradable Polymer Microparticles Using a Microfluidic Flow-focusing Device for Controlled Drug Delivery.” Small, 2009, 5, 1575-1581.
  35. Mei, Y.; Cannizzaro, C.; Park, H. S.; Xu, Q.; Bogatyrev, S. R.; Yi, K.; Goldman, N.; Langer, R.; Anderson, D. G. “Cell-compatible, Multicomponent Protein Arrays with Subcellular Feature Resolutions.” Small, 2008, 4, 1600-1604.
  36. Cho, S. W.; Hartle, L.; Son, S. M.; Yang, F.; Goldberg, M.; Xu, Q.; Langer, R.; Anderson, D. G. “Delivery of Small Interfering RNA for Inhibition of Endothelial Cell Apoptosis by Hypoxia and Serum Deprivation.” Biochemical and Biophysical Research Communications, 2008, 376, 158-163.
  37. Huo, B.; Lu, X. L.; Hung, C. T.; Costa, K. D.; Xu, Q.; Whitesides, G. M.; Guo, X. E. “Fluid Flow Induced Calcium Response in Bone Cell Network.” Cellular and Molecular Bioengineering, 2008, 1, 58-66. (Featured on the cover page)
  38. Xia, N.; Thodeti, C. K.; Hunt, T. P.; Xu, Q.; Ho, M.; Whitesides, G. M.; Westervelt, R.; Ingber, D. E. “Directional Control of Cell Motility through Focal Adhesion Positioning and Spatial Control of Rac Activation.” The FASEB Journal, 2008, 22, 1649-1659.
  39. Xu, Q.; Rioux, R. M.; Dickey, M. D.; Whitesides G. M. “Nanoskiving: A New Method to Produce Arrays of Nanostructures.” Accounts of Chemical Research, 2008, 46, 1566-1577. (Invited review)
  40. Xu, Q.; Rioux, R. M.; Whitesides G. M. “Fabrication of Complex Metallic Nanostructures by Nanoskiving.” ACS Nano, 2007, 1, 215-227.
  41. Xu, Q.; Bao, J.; Rioux, R. M.; Castillejos R. P.; Capasso, F.; Whitesides, G. M. “Fabrication of large-area patterned nanostructures for optical applications by nanoskiving.” Nano Letters, 2007, 7, 2800-2805. (Featured in Photonics.com 10/01/2007)
  42. Lahav, M.; Weiss, E. A.; Xu, Q.; Whitesides, G. M. “Core-Shell and Segmented Polymer-Metal Composite Nanostructures.” Nano Letters, 2006, 6, 2166-2171.
  43. Guo, X. E.; Takai, E.; Jiang, X. J.; Xu, Q.; Whitesides, G. M.; Costa, K. D.; Yardley, J. T.; Hung, C. T.; Chow E. M., Hantschel T, Costa K. D. “Intracellular calcium waves in bone cell networks under single cell nanoindentation.” Molecular Cellular Biomechanics, 2006, 3, 95-107.
  44. Xu, Q.; Castillejos R. P.; Li, Z.; Whitesides, G. M. “Fabrication of High Aspect Ratio Metallic Nanostructures by Nanoskiving.” Nano Letters, 2006, 6, 2163-2165.
  45. Xu, Q.; Bao, J.; Capasso, F.; Whitesides, G. M. “Surface Plasmon Resonance in Gold Nanowires Fabricated by Nanoskiving.” Angewandte Chemie International Edition, 2006, 45, 3631-3635.
  46. Jiang, X.; Xu, Q.; Dertinger, S. K. W.; Stroock, A. D.; Fu, T-M.; Whitesides, G. M. “A General Method for Patterning Gradients of Biomolecules on Surfaces Using Microfluidic Network.” Analytical Chemistry, 2005, 77, 2338-2347.
  47. Xu, Q.; Mayers, B. T.; Lahav, M.; Vezenov, D. V.; Whitesides, G. M. “Approaching Zero: Using Crystal Fracture as a Metric for Replica Molding.” Journal of the American Chemical Society, 2005, 127, 854-855.
  48. Cao, T.; Xu, Q.; Winkleman, A.; Whitesides, G. M. “Fabrication of Thin, Metallic Films along the Sidewalls of a Topographically Patterned Stamp and Their Applications in Charge Printing.” Small, 2005, 1, 1191-1195.
  49. Gates, B. D.; Xu, Q.; Steward M.; Ryan, D.; Wilson, C. G.; Whitesides, G. M. “New Approaches to Nanofabrication: Molding, Printing, and Other Techniques.” Chemical Reviews, 2005, 105, 1171-1196.
  50. Xu, Q.; Gates, B. D.; Whitesides, G. M. “Fabrication of Metal Structures with Nanometer-Scale Lateral Dimensions by Sectioning Using a Microtome.” Journal of the American Chemical Society, 2004, 126, 1332-1333.
  51. Xu, Q.; Tonks, I.; Fuerstman, M. J.; Love J. C.; Whitesides, G. M. “Fabrication of Free-standing Metallic Pyramidal Shells.” Nano Letters, 2004, 4, 2509-2511.
  52. Gates, B. D.; Xu, Q.; Thalladi, V. R.; Cao, T.; Knickerbocker, T.; Whitesides, G. M. “Shear Patterning of Microdominos: A New Class of Procedures for Making Micro- and Nanostructures.” Angewandte Chemie International Edition, 2004, 43, 2779-2783.
  53. Gates, B. D.; Xu, Q.; Love, J. C.; Wolfe, D. B.; Whitesides, G. M. “Unconventional Nanofabrication.” Annual Review of Materials Research, 2004, 34, 339–372.
  54. Cui, S. X.; Zhang, W.; Xu, Q.; Wang, C.; Zhang, X. “Supramolecular Research by Single Molecule Force Spectroscopy.” Macromolecular Symposium, 2003, 195, 109-114.
  55. Xu, Q.; Zhang, W.; Zhang, X. “Oxygen Bridge Inhibits Conformational Transition of 1,4-Linked alpha-D-galactose Detected by Single-molecule Atomic Force Microscopy.” Macromolecules, 2002, 35, 871-876.
  56. Xu, Q.; Zou, S.; Zhang, W.; Zhang, X. “Single-molecule Force Spectroscopy on Carrageenan by Means of AFM.” Macromolecular Rapid Communications, 2001, 22, 1163-1167.
  57. Zhang, W.; Xu, Q.; Zou, S.; Li, H.; Xu, W.; Zhang, X.; Shao, Z.; Kudera, M.; Gaub, H. E. “Single molecule Force Spectroscopy on Bombyx mori Silk Fibroin by Atomic Force Microscopy.” Langmuir, 2000, 16, 4305-4308.